Teaches kinesiology courses related to skeletal muscle anatomy, function, and the molecules that regulate muscle health.
His research is focused towards understanding the molecular and signaling mechanisms that regulate skeletal muscle mass.
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Education and Training
- PhD, MS, University of Louisville, Anatomical Sciences and Neurobiology
- MS, University of Kentucky, Kinesiology and Health Promotion (Biomechanics)
- BA, Hanover College, Hanover, Indiana, Exercise Science and Psychology
Dr. Bohnert's lab is interested in investigating the molecular mechanisms that regulate skeletal muscle atrophy during disease.
Specifically, Dr. Bohnert is interested in the role of a specific cell pathway called the Unfolded Protein Response (UPR) that's involved in maintaining skeletal muscle after sciatic nerve denervation.
Through collaborations with the SAU Biology Department and Palmer College of Chiropractic in Davenport, Dr. Bohnert's lab uses histology and immunohistochemistry to determine the expression level of various UPR components as well as the effect on neuromuscular junctions. These investigations will have broad impact on understanding of muscle atrophy experience during such pathologies as Parkinson's, Muscular Dystrophy, and ALS.
Bohnert KR, Gallot YS, Sato S, Xiong G, Hindi SM, Kumar A. (2016) Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia. FASEB Journal, 30: 3053-3068. PMID: 27206451. PMCID: PMC5001510
Xiong G, Hindi SM, Mann AK, Gallot YS, Bohnert KR, Cavener DR, Whittemore SR, Kumar A. (2017). The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. Elife pii: e22871. doi: 10.7554/eLife.22871. PMID: 28332979
Gallot YS, McMillan JD, Xiong G, Bohnert KR, Straughn A, Hill B, Kumar A (2017). Distinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesity. Oncotarget, 8:112565-112583. PMID: 29348847
Bohnert KR, McMillan JD, and Kumar A (2018). Emerging roles of ER stress and unfolded protein response pathways in skeletal muscle health and disease. Journal of Cellular Physiology, 233:67-78.
Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill B, Uchida S, Kumar A (2018). TAK1 is a key regulator of skeletal muscle mass and mitochondrial function. JCI Insight. 3(3). pii: 98441. doi:10.1172/jci.insight.98441.
Gallot YS, Straughn AR, Bohnert KR, Xiong G, Hindi SM, and Kumar A (2018). MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice. Hum Mol Genet. 2018 Jul 14. doi: 10.1093/hmg/ddy258.
Gallot YS, Bohnert KR, Straughn AR, Xiong G, and Kumar A (2018). PERK regulates skeletal muscle mass and contractile function in adult mice. FASEB Journal (Accepted).
Functional and Structural Kinesiology
Senior Research I
Exercise Physiology Lab
Exercise Biochemistry (graduate course)
Hayes Hall 239
518 W. Locust St.
Davenport, IA 52803